刘蓉

时间:2023-05-30 17:56:00编辑:优化君

1. Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R*, Wang JZ*.Zinc induces protein phosphatase 2Ainactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.Neurobiol Aging. 2012 Aug 11. [Epub ahead of print] PubMed PMID: 22892311 (* 通讯作者)

2. Sun XY, Wei YP, Xiong Y,Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R*, Wang JZ. Synapticreleased zinc promotes tau hyperphosphorylation by inhibition of PP2A. J Biol Chem.2012,287(14):11174-11182. (* 通讯作者)

3. Liu R*,

Wang JZ. Proteinphosphatase 2A inAlzheimer's disease. Pathophysiology. 2009 Oct;16(4):273-7. (* 通讯作者)

4. Liu R

, Zhou XW, Tanila H,Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JA,Winblad B, Pei JJ. Phosphorylated PP2A (tyrosine 307) is associated withAlzheimer neurofibrillary pathology. J Cell Mol Med. 2008,12(1):241-57.

5. Liu R

, Zeng J, Zhou XW, PeiJJ, Wang JZ. Effect of inhibiting tyrosine kinase Src expression on proteinphosphatase 2A and tauphosphorylation. Frontiers of Medicine in China.2008,2,235-238.

6. Liu R,

Pei JJ,Wang XC,Zhou XW, Tian Q, Winblad B,Wang JZ. Anoxia induces tau dephosphorylation through protein phosphatase-2A activation in rat brain slices.J Neurochem 2005,Sep;94(5):1225-1234.

7. 刘蓉

,王小川,黄尧,何志松,楮淑娟,汤芸,田青,王建枝. 急性缺氧和急性低糖对脑片tau蛋白磷酸化的影响。生物化学和生物物理进展2004,31(5): 402-408.

8. LiuR,

Wang XC, ZhouXW, Fang ZY, Tian Q, Pei JJ, Wang JZ. Acute hypoxia induces dephosphorylationof Tau in rat brain slices.Neurobiology Aging2004,25(2):432 (Abs)

9. Yu G, Li Y, Tian Q,

Liu R

, Wang Q, Wang JZ, Wang X. Berberineattenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation inHEK293 cells. J Alzheimers Dis. 2011 Jan 1;24(3):525-35.

10. Wang HH, Li HL

, Liu R

,Zhang Y, Liao K, Wang Q, Wang JZ, Liu SJ. Tau overexpression inhibits cellapoptosis with the mechanisms involving multiple viability-related factors. JAlzheimers Dis. 2010 Jan;21(1):167-79.

11. Liu XA, Liao K,

Liu R

,Wang HH, Zhang Y, Zhang Q, Wang Q, Li HL, Tian Q, Wang JZ. Tau DephosphorylationPotentiates Apoptosis with the Mechanisms Involving a FailedDephosphorylation/Activation of Bcl-2. J Alzheimers Dis. 2010;19(3):953-62

12. Zhou XW, Gustafsson JA,Tanila H, Bjorkdahl C,

Liu R

, Winblad B, Pei JJ. Tauhyperphosphorylation correlates with reduced methylation of protein phosphatase2A.Neurobiol Dis.2008,31(3):386-394.

13. Wang Q, Tian Q,

Liu R

, Liu zz, Hu mq, Ke D, Zhang sh; Wang xc. Pre-treatment with melatonin inhibits oleic acid-induced acute lung injury in rats.Chinese Journal of Pathophysiology. 2007, 4, 767-771.

14. Fang J,

Liu R

, Tian Q, Hong XP, Wang SH, Cao FY, Pan XP, Wang JZ. Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices.Acta Pharmacol Sin. 2007,28(11):1717-23.

15. Wang SH, Zhu LQ, Shi HR, Zheng HY, Wang Q,

Liu R

, Wang JZ, Inhibition of Melatonin Biosynthesis Induces Neurofilament Hyperphosphorylation with Activation of Cyclin-dependent Kinase 5.Neurochemical Research 2007, 32(8):1329-1335.

16. An WL, Bjorkdahl C,

Liu R

, Cowburn RF, Winblad B, Pei JJ. Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH-SY5Y neuroblastoma cells.J Neurochem 2005,92(5):1104-1115.

17. HuZH, Wang XC, Li LY, Liu ML,

Liu R

, Ling Z, Tian Q, Tang XW, Wu YG, WangJZ. Correlation of behavior changes and BOLD signal in Alzheimer-like ratmodel.Acta Biochim Biophys Sin (Shanghai) 2004,36(12):803-810.

18. FangZY, Liu SJ, Wang XC,

Liu R,

Wang Q, Chen ZY, Wang JZ. Effect of calpainon the degradation of tau protein in rat brain cortex extracts.Sheng Wu HuaXue Yu Sheng Wu Wu Li Xue Bao; 2003,35(7): 629-634.

19. SunL, Liu SY, Zhou XW, Wang XC,

Liu R

, Wang Q, Wang JZ. Inhibition ofprotein phosphatase 2A andprotein phosphatase 1-induced tau hyperphosphorylation and impairment ofspatial memory retention in rats.Neuroscience; 2003,118(4):1175-1182.

20. WangJZ, Wang XC,

Liu R

, Wang Q, Grundke-Iqbal I.Iqbal K. In vitro analysisof tau phosphorylation sites and its biological activity.Acta AcademiaeMedicinae Sinicae; 2002,17(1):13-16.

2013-2016 国家自然科学基金700,000 RMB Tau-PP2A-Src 复合体对NMDA 受体的异常调控在阿尔茨海默病发生中的作用 项目负责人

2013-2016 国家自然科学基金中加老年痴呆症及相关病症合作研究项目3,000,000 RMB GSK-3 介导Aβ, tau 和胰岛素相关阿尔茨海默样突触和胆碱能损伤的机制研究 第二完成人

2012-2013 华中科技大学自主创新研究基金50,000 RMB CIP2A对PP2A 的调节及其在阿尔茨海默病发病中的作用项目负责人

2010-2012 华中科技大学自主创新研究基金 70,000 RMB 锌离子对蛋白磷酸酯酶2A的调节和机制 项目负责人

2009-2011 国家自然科学基金200,000 RMB 下调磷酸酯酶抑制因子对老年性痴呆的保护作用及机制研究 第二完成人

2009-2011 国家自然科学基金80,000 RMB SET核转运及其对PP2A活性影响 第二完成人

2009-2011 国家自然科学基金200,000 RMB 白质星形胶质细胞内S100A4 蛋白抑制DRG神经元突起生长的机理研究 第二完成人

2006-2008 国家自然科学基金240,000 RMB 蛋白磷酸脂酶2A的酪氨酸磷酸化修饰在AD发病中的作用 项目负责人

2005-2006 瑞典Stiftelsen Gamlatj渀愀爀椀渀渀漀爀基金 30,000 Kr 项目负责人

2005-2006 瑞典Gun Och Bertil StohnesStifielse基金 25,000 Kr 项目负责人

2000-2001 同济医学院青年基金(姜学谊基金)3,000 RMB 项目负责人

急性能量代谢障碍对微管相关蛋白Tau的影响 2005年获湖北省优秀硕士学位论文奖

蛋白磷酸酯酶2A的酪氨酸磷酸化修饰在Alzheimer病发病中的作用 2008年获湖北省优秀博士学位论文奖

蛋白激酶在阿尔茨海默病tau蛋白过度磷酸化中的作用及应用价值 2008年获中华医学科技奖二等奖

Tau蛋白过度磷酸化的机制及其对神经元生存命运的影响 2009年获教育部高等学校科学研究优秀成果奖自然科学奖一等奖

2008年获华中科技大学青年教师讲课比赛二等奖

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimerneurofibrillary pathology,2010年获武汉市首届优秀学术论文奖

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